As we understand together, the West and Islam are the two great and important civilizations that exist on earth today, with their own character and characteristics. In a historical perspective, these two civilizations have made a long interaction in bitter and sweet situations for many centuries. Their relationship is colored by the process of mutual learning, mutual giving, and mutual acceptance, in addition between the two also never happened harmonious, conflict, and collision. In the context of the above, to organize the future of a peaceful, just and prosperous world, it is appropriate that the West and Islam learn from long past history, evaluate past conditions and conflicts so that we can together take positive wisdom in order building a future for a better humanity. For that is required the attitude of mutual acceptance and appreciate the differences of each. The West, which now dominates the world leadership, should ideally provide exemplary highlights for other civilizations, in a joint mission of realizing a peaceful, just and prosperous human life. On the contrary, the Islamic world must also be able and willing to learn from the various positive aspects of Western civilization, without abandoning the fundamental values ​​of Islam. In fact, if the West honestly recognizes the great contribution of the world. Islam towards Western civilization in the past, undoubtedly the attitude of mutual understanding and mutual respect between civilizations will be more easily built. To resolve the conflict, there needs to be mutual understanding and tolerance that must be internalized on each side. The cultural dialogue between Islam and the West is a damper for intercultural clashes. If it is ignored, the future of the world will certainly be even more gloomy and will only accelerate the "doomsday". Peace must be a fixed price that can not be negotiable.