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Not a huge difference to be honest- I used to work big, usually no smaller than 594 x 841 mm but often as big as I could make the frames for my canvases. I've actually gone smaller for my daily blogging as it is easier to scan and photograph smaller pieces - I still work large scale for commissions.

I was even thinking that doing a smaller scale is actually more difficult as you need to be more precise with hand movements. Small also looks cute, the bigger does not always mean better. Great painting regardless the size. Joy to follow your work.