Generally I have always followed my gut feeling and most of the time it has been a wise choice. The one exception to this general rule is investing especially trading. Following your gut feeling in this domain can be very profitable but the risks of not admitting when you are wrong which I think we as humans are loathe to do, can be extremely costly and that is why so many people lose money with trading / investments. Especially if you are trading you need to master the concept of taking losses early which is easier said than done.