My father in law was taking Juice Plus back when the Vineyard was in production. My husband talked them into letting him have them early. He took 5 doses a day of the "red green and purple" as I call them and lived years longer than expected. We really believe that is a big reason why. I had a lot of improvement on them but had to come off because of the added folic acid as I figured out I have MTHFR and couldn't process it. I've been round and round with the biomed guy and Mitra Ray to get it out of there! They need to get with it! That being said I do have a lot of patients on it!