Someone sure did - using bits of nutrition and plasmodium they found that Plasmodium naturally developed the most efficient routes to as yet undiscovered nutrition sources, which turned out to mimic the Tokyo subway system layout quite well.

At some point I hope to get some time lapse of this stuff in myself. So far I've only caught the less exciting non-plasmodial development on time lapse in this brief video

(This is my story account fyi)