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RE: Science Brief: Early Work On A Nanoparticle Aimed At Treating Alzheimers Disease
WRONG!
Suzanne de la Monte, a neuropathologist at Brown University, has been working on these phenomena in humans and rats. When she blocked the path of insulin to rats’ brains, their neurons deteriorated, they became physically disoriented and their brains showed all the signs of Alzheimer’s. The fact that Alzheimer’s can be associated with low levels of insulin in the brain is the reason why increasing numbers of researchers have taken to calling it Type 3 diabetes, or diabetes of the brain.
Alzheimer's Disease is Type 3 Diabetes: Evidence from Human Studies
This hypothesis was directly investigated by first examining postmortem cases of advanced AD and determining if the neurodegeneration was associated with significant abnormalities in the expression of genes encoding insulin, IGF-1, and IGF-2 peptides, their receptors, and downstream signaling mechanisms.5 In that study, we demonstrated advanced AD to be associated with strikingly reduced levels of insulin and IGF-1 polypeptide and receptor genes in the brain (Figure 1). In addition, all the signaling pathways that mediate insulin and IGF-1-stimulated neuronal survival, tau expression, energy metabolism, and mitochondrial function were perturbed in AD. This study carries additional significance because it established that, like all other pancreatic and intestinal polypeptide genes, the insulin gene was also expressed in the adult human brain. Moreover, the results taught us that endogenous brain deficiencies in insulin, IGF-1, IGF-2, and their corresponding receptors, in the absence of T2DM or obesity, could be linked to the most common form of dementia-associated neurodegeneration in the Western hemisphere. Since the abnormalities identified in the brain were quite similar to the effects of T1DM or T2DM (though none of the patients had either of these diseases), including abnormalities in IGFs,81–83 which are important for islet cell function,84,85 we proposed the concept that AD may represent a brain-specific form of diabetes mellitus and coined the term “type 3 diabetes.”
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/
So? I don't agree with the assessment to call it diabetes. Diabetes is a systemic terminology, effecting many systems. In fact usage of the term diabetes for both type 1 and type 2 is a poor idea, as they are two largely dissimilar diseases. Calling Alzheimer's type 3 diabetes is disingenuous at best, regardless of whether or not brain insulin sensitivity can induce Alzheimer's like symptoms in mice.
Read the human studies.
I have taught many ND's and MD's in my career.
Of course, I will take a closer look at the article you presented here for my train commute reading.
Enjoy the read.
Have a good weekend.
Will do, you as well.
thanks pal.
Were all here to help one another as a true community.