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RE: Paracetamol-induced Liver Toxicity: The thin line between Taking a pain killer and destroying your Liver

in #science • 7 years ago

Great post and your explanation of the physiology and pathophysiology are on point.

I agree with your doses on chronic use and toxicity but I I've never seen a value of 6g/ day as a toxic limit acutely?

The normally quoted toxic limit is about 150mg/kg which is about 12 grams in the average adult. Even this is quite a conservative figure.

Thanks again :)

7 years ago in #science by
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     7 years ago 

    Hi @tfcoates, thanks for dropping by and sharing your thoughts. From the information I have, the toxic limit varies in different individuals. For some, the sulfation pathway gets saturated at values close to 6g, while some individuals can take much higher doses.

    in all, I believe that it is still best to stay within the recommended doses.

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       7 years ago 

      Awesome, thanks for the clarification! I agree, best to play it safe. Always a good idea to avoid a lawsuit :p

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