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Are you spending your time commenting on large accounts hoping they will follow you?

I don't know that's always the case...Sure, there are some dicks out there who don't bother talking to you unless you're of a certain rep, but hey, those people ignore users with rep in their 50s, so...
Other than that, I've seen a lot of high rep users engage with newbies, as long as the comment is worthwhile and not resembling spam...