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RE: What Biologists do all Day - Structural Biology AGAIN

in #steemstem7 years ago

Very concise and thoughtful article!
I have one question tho, as a result protein-liquid mix you either get protein or crystal - or is it crystal every time (given enough amount of time).

And all the crystals look like building blocks of replicators from Stargate SG-1 :)))
Cheers!
P.S.
When I was in high school it was a tough call between biology and astrophysics. I went for astrophysics, but still love biology before all other sciences.

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There are several things that can happen. The protein can just fall out and not crystallize at all. Different forms of useless crystals can form (like the needles). Or ... no crystal at all:

40x klarer tropfen B1 25 zp2.jpg

Thanks for clarification. :)

Many proteins are impossible to crystallize at date, i´ve tried 4000 mixes on a single protein with out a trace of crystal :)) 4000 is not so much thou its just 40 x micro arrays with 100 different crystallization spots/mixes(as seen in the article) and a robot does all the work so just pray for crystals :)