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RE: A - What is the evidence that HIV causes AIDS?
I like the concluding paragraph, some think of AIDS as one disease. This was pretty detailed. Also interesting is the chimpanzees reference and some of the group that their SIV does not progress to AIDS, I think we have the same parallel in human as seen in some people from the Northern Europe.
Ah! The CCR5 mutation. Some of them are even resistant to getting infected by HIV in first place. It would be interesting to know which primates have if any have a mutated CCR5 selection in past. That could provide a good animal model to understand how this pathway works and develop drugs that can protect all humans from HIV infection. Or we can create the animal models with this mutation
Chimpanzees, however are also known to have gone through a selective sweep in their HLA repotire. This has indeed a lot to do with the long term human non progressors with HLA B27 and B57 variant.
Thanks for reading and your feedback. It always motivating to have discussion in comments of the post.
This is a time that I actually envy people with mutations :)